Most NSAID are weak organic acids that are well absorbed following PO administration. However, food can impair the oral absorption of some NSAID (eg, phenylbutazone, meclofenamate, flunixin meglumine) in horses and ruminants. Several NSAID are available as parenteral formulations for IV,

Most NSAID are biotransformed in the liver to inactive metabolites that are excreted either by the kidney via glomerular filtration and tubular secretion or by the bile.