![Antimicrobial activit4](https://xn--mgbaaebccr4cxezfcdfg0g.com/wp-content/uploads/2018/04/ANTIMICROBIAL-ACTIVIT4.jpg)
Mode of Action : They interfere with protein synthesis by reversibly binding to the 50S subunit of the ribosome. The effect is essentially confined to rapidly dividing bacteria and mycoplasmas. Macrolides are regarded as being bacteriostatic, but at high concentrations demonstrate bactericidal activity.
Macrolides are significantly more active at higher pH ranges (7.8-8).
![m2pack.biz](https://xn--mgbaaebccr4cxezfcdfg0g.com/wp-content/uploads/2023/10/m2pack.com_2.jpg)