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Lincomycin has a limited spectrum against aerobic pathogens but a fairly broad spectrum against anaerobes.
Clindamycin is a more active analog with somewhat different pharmacokinetic patterns. Many gram-positive cocci are inhibited by lincosamides, but most gram-negative organisms and most mycoplasmas are resistant,
Bacteroides spp and other anaerobes are usually susceptible.
Clostridium difficile strains appear to be regularly resistant.
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