Narrow-Spectrum Aminoglycosides

Included in this group are streptomycin and dihydrostreptomycin, which are mainly active against aerobic, gram-negative bacteria. Streptomycin and dihydrostreptomycin are characterized by narrow spectra, and efficacy is limited by bacterial resistance. Selected staphylococci and a number of gram-negative bacilli are still susceptible, including strains of Actinomyces bovis, Pasteurella spp, E coli, Salmonella spp, Campylobacter fetus, Leptospira spp, and Brucella spp. Mycobacterium tuberculosis is also sensitive to streptomycin.