Neomycin, framycetin (neomycin B), paromomycin (aminosidine), and kanamycin have broader spectra than streptomycin that often include several gram-positive as well as many gram-negative aerobic bacteria (E coli and Salmonella, Klebsiella, Enterobacter, Proteus, and Acinetobacter spp.). Gentamicin, tobramycin, amikacin (synthesized from kanamycin), sisomicin, and netilmicin are aminoglycosides with extended spectra that include Pseudomonas aeruginosa.