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Enhanced nephrotoxicity may become evident with concurrent administration of aminoglycosides and other potentially nephrotoxic agents. Aminoglycoside ototoxicity is enhanced by the loop-acting diuretics, especially furosemide. High concentrations of carbenicillin, ticarcillin, and piperacillin inactivate aminoglycosides both in vitro and in vivo in the presence of renal failure
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