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- For some organic bases-tissue concentrations » plasma concentrations.
- True for: erythromycin, clindamycin, trimethoprim, and metronidazole.
- Extreme for: azithromycin, clarithromycin, tilmicosin, tulathromycin
Absorption
- For chloramphenicol: oral is usually good; im or sc is usually good through there is some controversy between dose forms.
For Macrolides and lincosamides:oral is usually good; im or sc is usually good
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