Absorption

Lincomycin is incompletely absorbed from the Gl tract, especially if administered soon after feeding

Oral dose of clindamycin is absorbed, and effective plasma concentrations are achieved more rapidly than with lincomycin. Absorption is not significantly affected by the ingestion of food.

Clindamycin palmitate is used PO, and clindamycin phosphate IM

Distribution

Lincosamides are widely distributed in many fluids and tissues, including bone, Biotransformation

After administration PO, ~50% of a dose of lincomycin and 80-90% of a dose of clindamycin are metabolized in the liver.

Excretion

Unchanged antibiotic and several metabolites may be excreted in bile and urine. Concentrations remain high in the feces for some days.