Chloramphenicol is used to treat both systemic and local infections. Chronic respiratory infections, bacterial meningoencephalitis, brain abscesses, ophthalmitis and intraocular infections, pododermatitis, dermal infections, and otitis externa are types of bacterial infections that are often responsive to chloramphenicol. Salmonellosis and Bacteroides sepsis are fairly specific indications. Urinary tract infections are often successfully treated with chloramphenicol. Hematogenous delivery of chloramphenicol to the site of infection may play a role in these cases. Florfenicol is approved for use in treatment of bovine respiratory disease.