 . Basic Pharmacokinetics of Antimicrobial Drugs. |
|||
| Absorption | Distribution | Elimination | |
| Aminoglycosides | None oral; Good IM, SC | Extracellular fluid only (ECF); Not CNS | Renal (filtration) |
| Cephalosporins | Fair oral; Good IM, SC | ECF; Some get CNS
|
Renal (acid pump); Renal (filtration) |
| Fluoroquinolones | Good oral | TBW | Renal (filtration) |
| Macrolides
|
Variable oral; Fair to Good IM | TBW;Good intracellular | Hepatic (secretion); Hepatic (metabolism) |
| Penicillins | Variable oral; Variable IM, SC | ECF; Variable with drug | Renal (acid pump); Renal (filtration) |
| Sulfonamides | Good oral; Good IM | ECF, TBW | Renal (filtration); Hepatic (metabolism); Hepatic (secretion)
|
| Tetracyclines | Variable oral | TBW
|
Renal (filtration); Gl (doxycycline) |
