Antibiotics
Routes of Administration
| Oral Administration | |
| Availability | Most activities available
Oral aminoglycosides are “topical” (for Gl tract infection) |
| Appropriate Uses | Appropriate for mild to moderate infections but NOT for life threatening infections and NOT for systemic aminoglycoside action |
| Patient
Pharmacokinetics |
Absorption is always the most variable (as compared to IM, SC) between patients. Even greater variability is likely with disease states such as enteritis, motility disorders, Gl blood flow disturbances, Liver disease.
Oral is only rarely used for ruminants as drugs are metabolized by rumen microflora and only slowly released from the Rumen.
Oral is rarely a good route for horses (though it is often used). Amounts of drug unabsorbed may lead to flora alterations and severe Gl disease. There are few appropriate dose forms available. |
