• Amikacin
• Amikacin is not inactivated by as many bacterial enzymes as is the case for the previous class.
• Amikacin is selected when there is concern about resistance to gentamicin (and others in its class).
• Amikacin is also selected because it is believed to be less toxic than gentamicin. While this is technically true, the difference is not enough to justify the expense of the amikacin and it certainly should not put you at ease in terms of its clinical use.