Ampicillin & Amoxirillin

Antimicrobial activit1
Antimicrobial activit1

(Broad Spectrum Aminobenzyl Penicillins)

 

  • More lipid soluble than pen G so more active against Gram (-)
  • Better oral absorption (more stable in acid)
  • Just as susceptibile to penicillinase
  • Hydrolyze in water.

 

The difference between ampicillin and amoxicillin is that amoxicillin is slightly more lipid soluble than ampicillin. It (may) kill bacteria a little quicker, slightly better more of it is absorbed (and more rapidly). Otherwise, it is essentially the same activity.

Activity Profile (aminopenicillins):

Good as for benzyl Penicillin but also Borrelio, Leptospira, Moraxella

Moderate as for benzyl penicillin and Campylobacter, R. equi, and enterococci

Resistant Constitutive: Bacteroides fragilis, B.

bronchiseptica, Citrobacter, Enterobacter, Klebsiella, other Proteus, P. aeruginosa, Serratia, Y. enterocolitica.Acquired: Actinobacillus, E. coli, P. mirabilis, and Salmonella, and widespread resistant

by Enterobacteriaceae (though they are considered part of the general spectrum).

 

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