Biotransformation, Excretion,

 

 

Biotransformatio1
Biotransformatio1

The aminoglycosides are excreted unchanged in the urine by glomerular filtration, with 80-90% of administered drug recoverable from the urine within 24 hr of IM administration Excessive accumulation (mainly in the renal cortex) leads to a characteristic tubular cell necrosis

 

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