is a sulfonamide given PO as a suspension for infections with (mainly) adult liver flukes in sheep and cattle and as a SC injection for cattle, in combination with ivermectin. In plasma, clorsulon is bound to protein and, when ingested by liver flukes, inhibits enzymes of the glycolytic pathway. Clorsulon has a wide safety margin and is licensed for use in some countries (eg, Australia) in lactating dairy cows producing milk for human consumption. It is not licensed in Europe or the USA.