| divided BID- TID Horses: 2550 mg/kg, IV; repeat in 30 min if necessary Foals: 0.02-0.4 mg/kg, IV; repeat in 30 min if necessary | |||||
Second-line <Add-on) Anticonvulsant
|
|||||
| Clonazepam | Dogs:0.1-0.5 mg/kg, PO, BID -TID | 1.5-3 hr | 22-77 ng/mL | Extremely potent benzodiazepine; sedation, withdrawal signs if drug stopped abruptly.
|
|
| Clorazepate | Dogs: 2-6 mg/kg, PO.BID | 5-6 hr | I -2 days | 20-75 mg/L | 15 times less
potent than clonazepam; sedation, withdrawal seizures. |
| Felbamate | Dogs: 15 mg/kg,PO,tid; increase by 15
mg/kg biweekly until seizures controlled; maximal (toxic) dosage 300 mg/kg |
5-6 hr | 1 day | 125-250 mmol/L | Blood dyscrasia; induces P450 system, liver disease. Use with care with other potentially hcpatotoxic drugs. |
| Gabapentin | Dogs: 25-60 mg/kg, PO, divided TID- qid; 100-300 mg/dog, TID | 3-4 hr | <24 hr | 4-16 rngl/ (70-120 mmol/L) | Sedation, dizziness, ataxia, fatigue, diarrhea; reduce dose with renal dysfunction. |
| Levetiracetam | Dogs: 20 mg/kg, PO,TID; 500-4,000 mg/day | 4-10 hr | 2-3
days |
35-120 mmol/L | Restlessness, vomiting, ataxia at dosages >400 mg/kg/day. |
| Topiramate | Dogs: 5-10 mg/kg/day, PO,
divided BID
|
12-30
hr |
3-5
days |
2-25 mg/L (15-60 mmol/L) | GI upset, irritability |
