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| Availability | Most activity profiles are available (all aminoglycosides, all tetracyclines, chloramphenicol, macrolides, all representative actions for beta-lactams, most sulfonamides). Some questionable forms exist (48% Tribrissen) |
| Appropriate Uses | Life threatening infections; when intramuscular is contraindicated (due to tissue irritation, severe dehydration, thrombocytopenia, hemostatic disorder, etc.); to avoid injection site residues (food animals); rarely when steady sustained concentrations are desired (by constant intravenous infusion) |
| Patient
pharmacokinetics
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IV is the most predictable routes. Most iv “bolus” antibiotics should be given over 5 – 30 minutes as peak concentrations may be toxic (or waste drug). Continuous (steady state) infusions no longer in vogue. |
