Absorption

Absorption occurs promptly and rapidly from the upper Gl tract when chloramphenicol base is administered PO to nonruminant animals.

Chloramphenicol is inactivated in the ruminoreticulum and is not available for absorption. The presence of food and intestinal protectants does not interfere with the absorption of chloramphenicol, although drugs that depress Gl motility do. Florfenicol is rapidly absorbed after administration PO, although milk interferes with absorption.

Chloramphenicol sodium succinate may be injected both IV and IM.