. Basic Pharmacokinetics of Antimicrobial Drugs. |
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Absorption | Distribution | Elimination | |
Aminoglycosides | None oral; Good IM, SC | Extracellular fluid only (ECF); Not CNS | Renal (filtration) |
Cephalosporins | Fair oral; Good IM, SC | ECF; Some get CNS
|
Renal (acid pump); Renal (filtration) |
Fluoroquinolones | Good oral | TBW | Renal (filtration) |
Macrolides
|
Variable oral; Fair to Good IM | TBW;Good intracellular | Hepatic (secretion); Hepatic (metabolism) |
Penicillins | Variable oral; Variable IM, SC | ECF; Variable with drug | Renal (acid pump); Renal (filtration) |
Sulfonamides | Good oral; Good IM | ECF, TBW | Renal (filtration); Hepatic (metabolism); Hepatic (secretion)
|
Tetracyclines | Variable oral | TBW
|
Renal (filtration); Gl (doxycycline) |