Table 5

 

Table 5
Table 5

. Basic Pharmacokinetics of Antimicrobial Drugs.

Absorption Distribution Elimination
Aminoglycosides None oral; Good IM, SC Extracellular fluid only (ECF); Not CNS Renal (filtration)
Cephalosporins Fair oral; Good IM, SC ECF; Some get CNS

 

Renal (acid pump); Renal (filtration)
Fluoroquinolones Good oral TBW Renal (filtration)
Macrolides

 

Variable oral; Fair to Good IM TBW;Good intracellular Hepatic (secretion); Hepatic (metabolism)
Penicillins Variable oral; Variable IM, SC ECF; Variable with drug Renal (acid pump); Renal (filtration)
Sulfonamides Good oral; Good IM ECF, TBW Renal (filtration); Hepatic (metabolism); Hepatic (secretion)

 

 

Tetracyclines Variable oral TBW

 

Renal (filtration); Gl (doxycycline)

 

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