Antibiotics

Distribution

About 40-60% of chloramphenicol in plasma is reversibly bound to albumin, and the free fraction readily diffuses into almost all tissues (including the brain); highest concentrations are reached in the kidneys, liver, and bile.

Transplacental diffusion is seen in all species, with concentrations of ~75% being reached in the fetus as compared with the dam. Chloramphenicol does not attain effective concentrations in normal synovial fluid but does so in septic arthritis.

Florfenicol also penetrates most body tissues, although penetration of CSF and aqueous humor is less than that of chloramphenicol. Florfenicol does penetrate the milk of lactating cows.